20 мая 2002 00:00 |
Myocardial preservation using celsior solution in cardiac transplantation: early results and 5−year follow-up of a multicenter prospective study of 70 cardiac transplantations
Background. Several storage methods using a wide variety of extracellular or intracellular solutions applied either as continuous perfusion, intermittent perfusion, or simple immersion of the heart have been commonly used. We have performed a prospective randomized multicenter study of 70 cardiac transplantation recipients to evaluate the Celsior solution for cardiac preservation.
Methods. Seventy consecutive patients were included in this trial and received a cardiac graft arrested and preserved with Celsior. The first follow-up period was 1 month. The mean age of the recipients was 49 years (range, 28 to 66 years), and 81.7% were male. The main disease was nonobstructive cardiomyopathy (64.3%). The age range of donors was between 14 and 56 years with a mean of 33 years. The majority of grafts (73%) were stored in 1 L of Celsior. A midterm follow-up at 5 years was performed and was 100% complete.
Results. The operative mortality (<30−day) rate was 6 of 70 (8.6%). Sixty-three patients (90%) had at least satisfactory hemodynamic measurements on day 2. The first postoperative echocardiograms showed good myocardial performance for 90% of the grafts. Actuarial survival rate at 5 years was 75% ± 5.1%.
Conclusions. The use of Celsior in cardiac transplantation was safe and very effective. This solution proved very valuable in at-risk patients.Keywords. cardiac transplantation, Celsior, heart preservation
Смотри также
20 мая 2002 | 00:05
Repetitive atrial flutter as a complication of the left-sided simple maze procedure
Background. Of 41 patients who had undergone a left-sided simple maze procedure, 4 (9.8%) developed repetitive tachycardia due to atrial flutter, and required radiofrequency catheter ablation.
20 мая 2002 | 00:05
Hemodynamic stability during 17 years of the Carpentier-Edwards aortic pericardial bioprosthesis
Background. Long-term stability of the hemodynamic performance of commercially available Carpentier-Edwards stented bovine pericardial aortic bioprostheses (Perimount RSR) is unknown. To anticipate
20 мая 2002 | 00:05
Long-term results of aortic valve regurgitation after repair of ruptured sinus of valsalva aneurysm
Background. We reviewed our 35-year-experience to investigate the determinants of long-term results of aortic valve regurgitation (AR) after surgical repair of ruptured sinus of Valsalva aneurysms
20 мая 2002 | 00:05
Long-term survival and quality of life in cardiac surgical patients with prolonged intensive care unit length of stay
Background. Patients with prolonged intensive care unit (ICU) stays after cardiac operations are labor intensive and expensive. We sought to determine whether exhaustive ICU efforts result in
20 мая 2002 | 00:05
Endothelial cell injury induced by preservation solutions: a confocal microscopy study
Background. We evaluated the effects of standard preservation solutions on cultured human greater saphenous vein endothelial cells.
Methods. Endothelial cells (eight strains) were preincubated
